Naruto Shippūden: Clash of the Five Shinobi Nations

Naruto Shippūden: Clash of the Five Shinobi Nations is a fighting game for the Nintendo Wii that takes the storyline of the manga straight from the beginning of Naruto Shippūden to the Killer Bee vs. Kisame arc.

Chronicles of the Shinobi (RPG Mode)
RPG Mode falls under three different modes that follow the storyline of Naruto Uzumaki, Sasuke Uchiha, and the Akatsuki.

Trivia

 * For the first time, a guest character from another series appears in a Naruto game.